Abstract

A highly stereocontrolled 1,2-trans-β-glycosidation reaction without neighboring group participation has been developed by using benzyl-protected glycopyranosyl diethyl phosphites as glycosyl donors and boron trifluoride etherate as a promoter. The present method exhibits the highest level of 1,2-trans-β-selectivity known to date for glycosidations with a non-participating group on O-2.

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