Abstract
BackgroundChanges in clinical practice are brought about by the weight of clinical evidence for and against an intervention. Clinical evidence of efficacy relies on the dissemination of research results, usually by publication in medical journals which is often seen as a pre-requisite for progression of an intervention through further clinical trials or implementation studies.How far has research progressed along the translational pathway?We undertook an exploratory exercise to determine where basic and translational medical research is currently published. Original research articles (329 in total) published in high impact general and specialist medical journals were classified into different stages of research within the translational medicine pathway.Where is translational research published?The general medical journals had the broadest spread of published research over the translational pathway. The specialist journals tended to be positioned to disseminate the research findings of early stage translational research from basic science results through to early stages of clinical testing.ConclusionIt is not possible for one journal to satisfy all the needs of the reader and the author along the translational medicine pathway. For an intervention to progress along the translational pathway background information should be readily accessible in the article. This pathway is currently being actively managed by the funding agencies but the next challenge is to ensure the pathway operates efficiently and does not allow promising innovations to languish and to provide a smoother transition for interventions to reach the clinic in a quicker timescale. It is clear that the dissemination of results in the right place at the right time is crucial to the transition of an intervention from the laboratory to clinical practice.
Highlights
The status of translational research has drawn increasing attention as it is seen to be essential to the development of new treatments from advances in biomedical science [1,2,3,4,5]
Clinical evidence of efficacy relies on the dissemination of research results, usually by publication in medical journals which in academic models is often seen as a prerequisite for progression of an intervention through further clinical trials or implementation studies
Both New England Journal of medicine (NEJM) and the Lancet had the smallest proportion of original articles devoted to basic science, which represented 11% and 6% respectively, whereas, Nature Medicine seemed to be clearly positioned at the basic science and early clinical studies end of the translational pathway, with 100% of its articles falling into this category
Summary
It is not possible for one journal to satisfy all the needs of the reader and the author along the translational medicine pathway. For an intervention to progress along the translational pathway background information should be readily accessible in the article. This pathway is currently being actively managed by the funding agencies but the challenge is to ensure the pathway operates efficiently and does not allow promising innovations to languish and to provide a smoother transition for interventions to reach the clinic in a quicker timescale. It is clear that the dissemination of results in the right place at the right time is crucial to the transition of an intervention from the laboratory to clinical practice
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