Abstract
This study demonstrates a novel application of effect-based toxicity testing for streams that may provide indications of co-perturbation to ecological and human health. For this study, a sediment contact assay using zebrafish (Danio rerio) embryos was adapted to serve as an indicator of teratogenic stress within river sediments. Sediment samples were collected from Lake Michigan tributary watersheds. Sediment contact assay responses were then compared to prevalence of congenital heart disease (CHD) and vital statistic birth indicators aggregated from civil divisions associated with the watersheds. Significant risk relationships were detected between variation in early life-stage (ELS) endpoints of zebrafish embryos 72 h post-fertilization and the birth prevalence of human congenital heart disease, low birthweight and infant mortality. Examination of principal components of ELS endpoints suggests that variance related to embryo heart and circulatory malformations is most closely associated with human CHD prevalence. Though toxicity assays are sometimes used prospectively, this form of investigation can only be conducted retrospectively. These results support the hypothesis that bioassays normally used for ecological screening can be useful as indicators of environmental stress to humans and expand our understanding of environmental–human health linkages.
Highlights
Evaluation of environmental health presents the challenging task of identifying useful quantifications of environmental health [1,2,3]
We propose that toxicity assays, such as those used in Effect-Directed Analyses (EDA), may provide useful indicators for similar analyses that evaluate toxicity of human-inhabited communities
Principal components were calculated for these responses and bi-plots showing the relationships are presented in Figures 3 and 4
Summary
Evaluation of environmental health presents the challenging task of identifying useful quantifications (indicators) of environmental health [1,2,3]. Increasing complexities regarding multiple interacting risk factors (chemicals, socio-economic conditions, built environment) suggest a need for cost-effective investigation of environmental exposures with potential human health consequences [4]. This topic is often studied through investigations of human health risk in association with environmental indicators. Others apply indices of biotic integrity as indicators of human health risk in regions where ecological systems are disturbed [8,9]. We propose that toxicity assays, such as those used in Effect-Directed Analyses (EDA), may provide useful indicators for similar analyses that evaluate toxicity of human-inhabited communities
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