An experimental study to investigate the impact of Aspirin and Vitamin C therapy on fructose induced hepatic and pancreatic damage

Abstract

It is assumed that excessive fructose consumption is associated with the risk of developing various diseases, especially metabolic disease. The aims of this study were two fold: 1) Does liver and pancreatic damage occur due to excessive fructose consumption 2) If damage occurs, can we reduce this damage by using (ASA) and Vit. C. The rats were divided randomly into five groups of eight as follows: Group1-control; Group2-corn syrup (Fructose: F; 30% F solution); Group3-F and ASA (F+10 mg/kg/day, ASA, oral); Group4-F and Vit. C (F+200 mg/kg/day, Vit. C, oral); Group5-F, ASA and Vit C (F+A+C -same dose administration, respectively). The rats were sacrificed 24 h after the last application at the end of the 6th week, and their blood serum, liver and pancreas tissues were taken and evaluated histologically and biochemically. It was found that serum cholesterol and AST levels were significantly lower in the F+C and F+A+C groups, and ALT and TG levels were significantly lower in the F+A+C group compared to the F group (p