Abstract
Background and Objectives: Diabetes is a chronic metabolic disorder that can effectively influences male reproductive performance. The present study was conducted to investigate the protective effects of Solanum lycopersicum essential oil (SL) on diabetes-induced testicular injuries. Materials and Methods: Adult male rats were randomly allocated into five groups (n = 8 in each group). 1: control; 2: diabetic; 3: diabetic + 30 mg/kg of SL essential oil; 4: diabetic + 90 mg/kg of SL essential oil; 5: diabetic + 270 mg/kg of SL essential oil extract. Diabetes was induced by a single dose of streptozotocin (55 mg/kg) intraperitoneally. Testicular changes were assessed quantitatively using stereological method followed by measuring antioxidant enzymes including catalase, superoxide dismutase, and glutathione peroxidase, and the serum testosterone level. Malondialdehyde (MDA) levels and Bcl-2expression were also evaluated in the tissue samples. Results: Diabetes resulted in significant deleterious changes in the structure of testicular tissue, suppressed antioxidant enzymes and testosterone levels, and increased lipid peroxidation. The expression of Bcl-2 was downregulated in diabetic testis and resulted in enhanced apoptosis. Following 8 weeks of treatment with SL essential oil, there were noticeable improvements in the structural changes of testis and the restoration of antioxidant defense and testosterone levels in testicular tissue, especially at higher doses. Conclusion: In conclusion, these findings reveal that the essential oil of Solanum lycopersicum has potent antioxidant properties and can attenuate the adverse effects of diabetes on male reproduction.
Highlights
Diabetes is a chronic metabolic disorder caused by disturbances in carbohydrate, protein, and lipid metabolism, and is mainly due to the decreased levels of insulin secretion or reduced sensitivity of target tissues [1]
The role of oxidative stress in the progression of reproductive dysfunction is not fully understood [6], it has been established that diabetes-induced oxidative stress
After grinding the dried seeds, the obtained powder was added to a distillation flask (1L) which was connected to a steam producer via a glass tube and to a condenser to collect the essential oil in a funnel tube
Summary
Diabetes is a chronic metabolic disorder caused by disturbances in carbohydrate, protein, and lipid metabolism, and is mainly due to the decreased levels of insulin secretion or reduced sensitivity of target tissues [1]. Experimental and clinical research on men and animal models has been shown that diabetes can effectively influence male reproductive system and results in reduced testosterone synthesis and secretion, impaired spermatogenesis, decreased libido and, eventually, infertility [2,3,4,5]. The role of oxidative stress in the progression of reproductive dysfunction is not fully understood [6], it has been established that diabetes-induced oxidative stress. Diabetes is a chronic metabolic disorder that can effectively influences male reproductive performance. The present study was conducted to investigate the protective effects of Solanum lycopersicum essential oil (SL) on diabetes-induced testicular injuries
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