Abstract
Vascular endothelial growth factor (VEGF) and its receptor (VEGFR2) are important for wound repair. The aim of this study was to investigate the effect of Zibai ointment on the expression of these factors in wound models. In order to establish wound models, a total of 120 rats were used, which were assigned to vaseline group, Zibai ointment group and erythromycin group. The granulation tissues in each group were obtained on the 3rd, 7th, 14th or 21st day after the establishment of the model. The methods such as immunohistochemistry, RT-PCR, and western blot were used to detect the expression of VEGF and VEGFR2. Comparing to the erythromycin group or vaseline group, the expression of VEGF and VEGFR2 in Zibai ointment group on the 21st day was much higher (P < 0 05). The results of scanning electron microscopy (SEM) showed that with time in the Zibai ointment group, the granulation tissue gradually formed dense reticular layers of loose, curly fibers, and presented with more collagen deposition. In conclusion, Zibai ointment could effectively improve the expression of VEGF and VEGFR2 in granulation tissues of wounds and promote wound healing.
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