Abstract
Transcranial focused ultrasound is increasingly being used as an alternative non-invasive treatment for various brain disorders, including essential tremor, Parkinson's disease, and neuropathic pain. These applications necessitate an understanding of the complex relationship between temperature and acoustic properties of cranial bone. In particular, the longitudinal speed of sound and attenuation coefficients will be investigated. In this study, ex vivo skull caps were heated to temperatures ranging from 20 to 50 °C, and ultrasound pulses were transmitted through the skull caps using a spherical transducer of 5 cm diameter and 10 cm focal length, at clinically relevant frequencies of 0.836 and 1.402 MHz. A thin Mylar film was placed at the focus, and a laser vibrometer was used to receive the ultrasound pulse transmitted through the skull. It was found that there was a measurable change in the phase and amplitude of the received signal, implying a change in both the speed of sound and attenuation of the bone at different temperatures. It was also found that these changes were completely reversible. These results imply that at sufficiently high cranial bone temperatures, the assumption of temperature-independent acoustic properties of bone may become invalid.
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