An Experimental Study on Blood Platelets and Pathological Granules of Neutrophiles in Rice=diseased and B<sub>1</sub>=avitaminotic Rats; and Change of Blood Platelets on an Admini=stration of Vitamin B<sub>1</sub>

Abstract

1. White rats fed on thoroughly washed polished rice or on diet free from vitamin B1 show an increase of blood platelet count. 2. But when polished rice or B1-free diet is long continued or when animals draw near death or are in the paralytic stage, the count decreases. 3. As to classification of blood platelets, the sum of spindle-shaped and small platelets show an increase when total count begins to increase or return to normal, and large platelets show an increase in the more advanced stage of B1 avitaminosis. 4. Vitamin B1 makes the increased blood platelet count smaller and renders the abnormal distribution of different platelets normal. 5. “Neutrophiles with pathological granules” already show an increase, though in a slight degree, then platelet count begins to increase. 6. Red cell count does not decrease in the terminal stage of B1 avitaminosis, but shows an increase when platelets reached the maximal count in most cases. 7. There is, as far as platelet count and pathological granules is concerned, no essential difference between the rice disease and B1 avitaminosis of rats.