Abstract
Direct agglomeration of sodium theophylline monohydrate crystals produced by salting out in a liquid was carried out in a stirred vessel. Addition of aqueous ethylenediamine solution of theophylline and sodium chloride solution to a mixture of chloroform and ethanol (mixing ratio of chloroform:ethanol = 0.1 to 0.505:1) with agitation yielded spherically agglomerated crystals of sodium theophylline monohydrate. The diameter of the spherical agglomerate decreased with increase in agitation speed of the chloroform fraction in the mixture. The spherical crystallization process was described by first-order kinetics. The rate constant was a function of the agitation speed of the system and the difference between the residual concentration of theophylline in the solvent in the initial and the equilibrium state.
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