Abstract
PurposeTo analyze the soft tissue reaction of ‘Titanium Silk’ mesh implant in comparison with ‘Parietene Progrip’ and ‘Prolene’ mesh implants for the reinforcement and augmentation of soft tissues to improve the results of static correction in Facial Paralysis and other defects of Maxillofacial region. Materials and methodsUnder standard laboratory conditions, 89 mice were divided into 4 groups: a control group of 5 mice; first group of 28 mice with Titanium mesh implant, second group of 28 mice with semi-resorbable ‘Parietene Progrip’ implant and third group of 28 mice with ‘Prolene’ implant. Under inhalational anesthesia with ethyl ether at days 7, 14, 30 and 60, seven mice from each experimental group underwent Gross and histological analysis of the mesh structures for the following characteristics: Macrophage Infiltration, Multinucleated Macrophages, Meshwork around the implant fibers, Connective tissue proliferation, Angiogenesis and Fibroblasts. ResultsHistological analysis revealed a significantly less pronounced inflammatory response to Titanium mesh implant resulting in the formation of a more delicate connective tissue network around the mesh elements. ConclusionThe experiment clearly demonstrated the cellular and tissue responses to different implantable mesh materials at various times of its integration. It revealed that the titanium mesh is the most bio-inert alloplastic material suitable for reinforcement of soft tissue augmentation and to prioritize it's use in static correction of facial paralysis and other defects of the maxillofacial region. A postoperative timeframe of 30 days is considered appropriate for the adequate formation of connective tissue around the mesh elements.
Highlights
The reconstructive challenge posed by complete facial paralysis is to optimally restore meaningful facial function and an acceptable cosmesis with minimal residual patient morbidity[1]. meshes are the most commonly used biomaterials in medical practice, with approximately 1.5 million implants used per year[2], numerous questions remain unaddressed about the host inflammatory response induced by mesh implants[3].The utilization of alloplastic material in plastic surgery has been widely accepted
Meshes are the most commonly used biomaterials in medical practice, with approximately 1.5 million implants used per year[2], numerous questions remain unaddressed about the host inflammatory response induced by mesh implants[3]
This experiment was performed to test the reaction of soft tissues to Titanium mesh implant (“Titanium Silk” developed by TsKB RAS, manufacturer: OOO TEMP, Yekaterinburg, Russia)
Summary
The reconstructive challenge posed by complete facial paralysis is to optimally restore meaningful facial function and an acceptable cosmesis with minimal residual patient morbidity[1]. meshes are the most commonly used biomaterials in medical practice, with approximately 1.5 million implants used per year[2], numerous questions remain unaddressed about the host inflammatory response induced by mesh implants[3].The utilization of alloplastic material (i.e. silicone prostheses, polypropylene mesh, etc.) in plastic surgery has been widely accepted. Experimental data reveal that material composition and mesh structure may significantly affect foreign body reaction.[10] Mesh characteristics such as pore size, chemical composition, filament structure, amount of implanted material, and biodegradability affect the processes of inflammation, angiogenesis, and tissue formation which may alter wound healing[11,12,13,14,15,16,17]. Experimental studies have shown that the inflammatory response of an organism toward titanium-coated meshes is much reduced when compared with other implants.[21,22] Bearing this in mind, this experiment was performed to test the reaction of soft tissues to Titanium mesh implant (“Titanium Silk” developed by TsKB RAS, manufacturer: OOO TEMP, Yekaterinburg, Russia)
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