Abstract
The use of an experimental design technique in the development of various pharmaceutical preparations, including tablet preparations, has become the latest trend. Because of their ease of use, tablet formulations are popular among both producers and patients. To increase the usage of tablets in diverse circles and settings, researchers are working to develop a variety of tablet excipients for various functions. Fast dissolving tablets (FDT), effervescent tablets, modified-release tablets, oral mucoadhesive tablets, gastroretentive tablets, and colon targeted tablets are some of the tablet formats that have been developed in addition to traditional tablets. This review will look at how formulation optimization in tablet preparations has been done during the previous ten years using specific literacies. The articles for this review were found using the keywords tablet, excipient, matrices, formulation, and QBD in specialized databases such as Elsevier, Pubmed, and Cambridge. Other options include Springer publications, material from the Internet, and articles published online by The Lancet Respiratory Medicine, Medscape, and Statpearls. The formulation design strategy is based on the experimental design approach carried out on the kind of tablet preparation, which has distinct important quality parameters.
Highlights
Quality by design (QBD) is a concept of a systematic approach in product development that begins with defining targets and emphasizing product understanding and process control, based on scientific justification and quality risk management
The factors that affect the quality of a product are identified early on and optimized simultaneously, systematically, and quickly using a technique called the design of experiment (DoE)
It's has been developed according to the type of tablet and the experimental design approach that has been used for development
Summary
Quality by design (QBD) is a concept of a systematic approach in product development that begins with defining targets and emphasizing product understanding and process control, based on scientific justification and quality risk management. Reviewing the additives in various tablets will be useful information for formulators in preparing the tablet design. Excipients are utilized in traditional tablets to keep BAF in a compressible mass that can be crushed to release Drug Material into body fluids.
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