Abstract
An expeditious synthesis of N-substituted pyrroles has been developed by reacting 2,5-dimethoxy tetrahydrofuran and several amines using a microwave-induced molecular iodine-catalyzed reaction under solventless conditions.
Highlights
Pyrroles are an important class of organic compounds with different types of medicinal activities [1,2], many methods for the synthesis of diversely substituted pyrroles have been developed [3]
We describe here a simple method of synthesis of N-substituted pyrroles by reacting 2,5-dimethoxytetrahydrofuran (1) and various amines in the absence of any solvent in a microwave oven in the presence of catalytic amounts
This reaction has been tested by reacting different types of amines 2 and 2,5-dimethoxytetrahydrofuran in a microwave oven in the presence of molecular iodine as a catalyst
Summary
Pyrroles are an important class of organic compounds with different types of medicinal activities [1,2], many methods for the synthesis of diversely substituted pyrroles have been developed [3]. We describe here a simple method of synthesis of N-substituted pyrroles by reacting 2,5-dimethoxytetrahydrofuran (1) and various amines in the absence of any solvent in a microwave oven in the presence of catalytic amounts (~5 mol%) of molecular iodine. This reaction produces pyrroles in excellent yield and within a short time under (Scheme 1).
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