An expeditious one-pot synthesis of novel bioactive indole-substituted pyrido[2,3-d]pyrimidines using Fe3O4@SiO2-supported ionic liquid nanocatalyst

Abstract

Novel bioactive 2-methylindole-substituted pyrido[2,3-d]pyrimidine derivatives were synthesized through an unprecedented one-pot three-component reaction of aromatic aldehydes, 6-amino-N,N-dimethyuracil, 3-(2-methyl-1H-indol-3-yl)-3-oxopropanenitrile in the presence of Fe3O4@SiO2-IL nanocatalyst as an efficient and magnetically retrievable catalyst. The assessment of antibacterial activity exhibited promising activities in most of the synthetic compounds.