An expeditious approach to tetrahydroindolizines from Morita- Baylis-Hillman Adducts

Fernando Coelho,José Tiago M Correia,Bruno V M Teodoro

doi:10.5151/chempro-15bmos-bmos2013_201310100158

Abstract

Indolizines are important building blocks for synthesis of biomarkers, drugs and alkaloids that posses the indolizidinic core. This type of heteroaromatic skeleton can be prepared using different approaches. Recently Morita-BaylisHillman adducts were used as building block for the synthesis of indolizidinic unity. However, applications of these molecules remain almost unexplored. In this communication, we disclosed our preliminary results on a simple strategy to access tetrahydroindolizines and indolizidines by partial or total hydrogenation of indolizines prepared from MBH adducts.

Highlights

Indolizines are important building blocks for synthesis of biomarkers, drugs and alkaloids that posses the indolizidinic core
Morita-BaylisHillman adducts were used as building block for the synthesis of indolizidinic unity[2,3]
We disclosed our preliminary results on a simple strategy to access tetrahydroindolizines and indolizidines by partial or total hydrogenation of indolizines prepared from MBH adducts

Summary

Introduction

Indolizines are important building blocks for synthesis of biomarkers, drugs and alkaloids that posses the indolizidinic core. Laboratory of Synthesis of Natural Products and Drugs, Institute of Chemistry, University of Campinas- This type of heteroaromatic skeleton can be prepared using different approaches.[1] Recently Morita-BaylisHillman adducts were used as building block for the synthesis of indolizidinic unity[2,3].

Results

Conclusion