Abstract
An efficient three-step synthesis of 5-substituted 2,3-dihydroimidazo[1,2-<i>c</i>]quinazolines and imidazo[1,2-<i>c</i>]quinazolines was elaborated. 2-(2-Aminophenyl)-4,5-dihydro-1<i>H</i>-imidazole, prepared by phosphorus pentasulfide catalyzed condensation of 2-aminobenzonitrile with ethylenediamine, smoothly reacted with aldehydes to give the corresponding 2,3,5,6-tetrahydroimidazo[1,2-<i>c</i>]quinazolines. The CH–NH fragments of the latter were subjected to selective oxidative dehydrogenation with one equivalent of potassium permanganate on silica gel to give 2,3-dihydroimidazo[1,2-<i>c</i>]quinazolines. With two equivalents of potassium permanganate on silica gel, a one-pot exhaustive dehydrogenation to imidazo[1,2-<i>c</i>]quinazolines was accomplished.
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