An expedient approach for the regioselective synthesis of novel 1,5,6,7-tetrahydro-2H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione derivatives via Fe (III)-mediated iodocyclization

Abstract

Novel pyrrolo[3,2-d]pyrimidine derivatives have been synthesized by an efficient and regioselective Fe (III)-mediated iodocyclization method starting from a commercially available uracil compound. Here, iron has a dual role in the iodocyclization process by acting as a Lewis acid which promotes the release of I+ cation from iodine by removing iodide ion, and also as an oxidant which again generates iodine from iodide ion to take part in the catalytic cycle.