Abstract

Neurons in visual cortex are connected not only locally but also through networks of distal connectivity. These distal networks recruit both excitatory and inhibitory synapses, and result in divisive normalization. Normalization is traditionally thought to result from increases in synaptic inhibition. By combining optogenetic stimulation and intracellular recordings in mouse visual cortex here we show that, on the contrary, normalization is due to a decrease in synaptic excitation.

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