Abstract
A wide variety of 1,3-oxathiolanes 1 can be chemoselectively deprotected to the corresponding carbonyl compounds 2 in good yields by employing V2O5–H2O2 catalyzed oxidation of ammonium bromide in a CH2Cl2–H2O mixture at 0–5 °C. Some of the major advantages of this procedure are its mild conditions, and that it is highly selective and efficient, high yielding, and cost-effective. Furthermore, no brominations occur at the double bond or allylic position or α to the keto position or aromatic ring.
Published Version
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More From: Journal of the Chemical Society, Perkin Transactions 1
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