Abstract
The relationship between the DNA content of an average bacterial cell in an exponential culture, the velocity of chromosome rePlication ( C), the time between replication termination and cell division ( D), and the doubling time ( τ), originally derived by Cooper and Helmstetter, is shown to be independent of two assumptions made by those authors. That is, it is not necessary to assume an ideal age distribution of cells in an exponential culture, and replication need not initiate synchronously at every DNA origin sequence within the cell. This implies that the relationship has a more general validity than has been previously supposed, and that agreement of observations on exponential cultures with the Cooper-Helmstetter theory cannot be taken to prove the assumptions on which that theory was originally based.
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