Abstract
Health-related quality of life (HRQoL) is recommended as one of essential parameters to evaluate treatment effect and clinical outcome in patients with Crohn's disease (CD). Recent studies reported that psychological factors might play a role in HRQoL in Western and American CD patients. Sufficient evidences in Chinese CD patients are still unavailable. This study is dedicated to investigate the correlation of various psychological factors with HRQoL in Chinese CD patients. We prospectively collected 40 active and 40 quiescent CD patients in China and found that psychological factors, especially neuroticism and anxiety, significantly correlate with and affect HRQoL in both active and quiescent CD groups. This is the first report revealing correlation between psychological factors and HRQoL in Chinese CD patients. Therefore, we assume that our results can contribute to a better understanding of etiology and tailoring of management in Chinese patients with Crohn's disease and are beneficial to our colleagues to compare the heterogeneous characteristics of Crohn's disease in different ethnic groups.
Highlights
Crohn’s disease (CD) is characterized by chronic, transmural intestinal inflammation in which periods of remission with variable length are interrupted by relapse episodes [1]
When Crohn’s disease activity index (CDAI) score was entered into this model, R square elevated dramatically to a statistical significant degree, indicating that
Psychological factors: ∙ Neuroticism and lie subscales of eysenck personality inventory ∙ Hospital anxiety and depression scale ∙ Buss-perry aggregation questionnaire disease activity was a significant covariant in the relationship between psychological factors and Health-related quality of life (HRQoL)
Summary
Crohn’s disease (CD) is characterized by chronic, transmural intestinal inflammation in which periods of remission with variable length are interrupted by relapse episodes [1]. A series of studies performed in Europe and North America reported several distinct psychological traits that relate to HRQoL and outcome of surgery in patients with CD [2, 4, 6, 7]. There is no report investigating correlation between psychological factors and HRQoL in Chinese patients with CD. All questionnaires adopted in current study have been validated for Chinese population
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