Abstract

IntroductionA semi-upright position in ventilated patients is recommended to prevent ventilator-associated pneumonia (VAP) and is one of the components in the Ventilator Bundle of the Institute for Health Care Improvement. This recommendation, however, is not an evidence-based one.MethodsA systematic review on the benefits and disadvantages of semi-upright position in ventilated patients was done according to PRISMA guidelines. Then a European expert panel developed a recommendation based on the results of the systematic review and considerations beyond the scientific evidence in a three-round electronic Delphi procedure.ResultsThree trials (337 patients) were included in the review. The results showed that it was uncertain whether a 45° bed head elevation was effective or harmful with regard to the occurrence of clinically suspected VAP, microbiologically confirmed VAP, decubitus and mortality, and that it was unknown whether 45° elevation for 24 hours a day increased the risk for thromboembolism or hemodynamic instability. A group of 22 experts recommended elevating the head of the bed of mechanically ventilated patients to a 20 to 45° position and preferably to a ≥30° position as long as it does not pose risks or conflicts with other nursing tasks, medical interventions or patients' wishes.ConclusionsAlthough the review failed to prove clinical benefits of bed head elevation, experts prefer this position in ventilated patients. They made clear that the position of a ventilated patient in bed depended on many determinants. Therefore, given the scientific uncertainty about the benefits and harms of a semi-upright position, this position could only be recommended as the preferred position with the necessary restrictions.

Highlights

  • A semi-upright position in ventilated patients is recommended to prevent ventilator-associated pneumonia (VAP) and is one of the components in the Ventilator Bundle of the Institute for Health Care Improvement

  • The flow diagram showing the steps we followed to identify the randomized controlled trial (RCT) fulfilling the inclusion criteria of our systematic review can be found in Additional file 1

  • The systematic review showed that it is uncertain whether a 45° bed head elevation is effective or harmful with regard to the occurrence of clinically suspected VAP, microbiologically confirmed VAP, decubitus and mortality, and that it is unknown whether a 45° bed head elevation for 24 hours a day causes thromboembolism or hemodynamic instability

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Summary

Introduction

A semi-upright position in ventilated patients is recommended to prevent ventilator-associated pneumonia (VAP) and is one of the components in the Ventilator Bundle of the Institute for Health Care Improvement. This recommendation, is not an evidence-based one. About 20 years ago, studies using radiolabeled enteral feeding have shown more aspiration of gastric contents in supine patients than in patients in a 45° position [2,3,4] None of these studies assessed the effect of a semi-upright position on VAP. An observational study demonstrated that a supine position during the first 24 hours of mechanical ventilation is an independent risk factor for VAP [5]. A prospective randomized animal study showed that a semi-upright position reversed the mucus flow in intubated sheep [7]

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