An Evaluation of the Reproductive and Developmental Effects of Tara Gum in Rats

Abstract

In a multigeneration reproduction study, tara gum or α-cellulose was administered to male and female Charles River CD rats as a dietary admixture at levels of 5% (50,000 ppm) through 3 successive generations. All matings consisted of 10 males and 20 females per group. All litters were maintained until they were at least 21 days old (end of lactation). Fertility was generally high, and there were no consistent, statistically significant, compound-related adverse effects on any of the parameters evaluated. It is concluded that tara gum, fed at a dietary level of 5% for 3 successive generations, did not adversely affect reproductive performance. In a study designed to assess embryotoxicity and teratogenicity, tara gum was administered as a dietary admixture to mated female rats at levels of 12,500,25,000, and 50,000 ppm from days 6 to 16 postcoitum. No deaths occurred and no compound-related signs or symptoms were observed. Necropsy findings were negative. Examination of fetuses yielded no evidence of embryonic and/or teratogenic potential of tara gum.