An evaluation of takata-ara reaction as a liver function test

Abstract

1. The Takata-Ara test is of value in hepatic affections in general, and in cirrhotic forms in particular. 2. It has a practical value in cases in which the symptomatology is doubtful or incomplete. 3. The test is easy to perform and not difficult to interpret in the light of other liver function tests. It merits the same consideration as other tests. 4. Factors are encountered which limit its diagnostic value from the standpoint of specificity, but none to render it valueless. 5. The positivity of the test at a time when the pathologic alterations are considerable does not militate against its inclusion into our laboratory work-up of a case. 6. Since clinical signs often fail to indicate which function of the liver is first involved, we must recognize the lack of correlation between the type of pathologic lesion and the function which is disturbed. 7. Specificity cannot be attributed to the reaction, analogically, as none may be ascribed to the erythrocyte sedimentation and other tests. 8. Takata-Ara reaction is based on complex processes, and is under the influence of various factors which account for lack of uniformity of opinion. According to some workers, the A/G quotient is equal to 1.0 in a positive T.A.R., and according to others, it varies between 1 and 1.7.