An Evaluation of Pharmacological Healing Potentialities of Phyllanthus emblica and Terminalia chebula on Experimental Rat Models

Abstract

Background: Plants are known to contain potent phytochemical compounds that possess valuable pharmacological properties against various ailments. The cost, inadequacy and adverse effects of conventional medications have urged the investigators to look for better, safer, economical and more effective alternatives. The widespread availability of plants and their fewer side effects serve as rational motives for the investigation. Phyllanthus emblica is used widely in traditional medicine to alleviate various moderate to severe diseases and known to possess analgesic, anti-inflammatory, anti–oxidant and hepatoprotective properties while T. chebula possesses anti-diabetic, anti-ulcerant, anti-microbial properties. In this study, we attempted to determine the therapeutic potentialities of dried Phyllanthus emblica and T. chebula fruits through in vivo and in silico approaches. Methods: Dried fruits of Terminalia chebula and Phyllanthus emblica were collected, washed, dried and ground to coarse powder, 40 gm of methanolic extract was obtained. Results: According to the relevant tests, the ethanolic extract of Terminalia chebula has a significant (p<0.05) or highly significant (p<0.01) effect on the animal model as an analgesic, anti-hypertensive, anti-hyperglycemic, and cardioprotective in a dose- and source-dependent manner. The body weight of the low dose pretreatment groups received 0.652 g/kg of Phyllanthus emblica, whereas the high dose pretreatment groups received 1.564 g/kg of extracts. Terminalia chebula extracts were given to low dosage pretreatment groups at 0.492 g/kg body weight and high dose pretreatment groups at 1.180 g/kg body weight. At regular intervals, vital indicators such the heart rate (HR), blood pressure (BP), blood glucose, SGPT, SGOT, creatinine, and lipid profiles (TG, TC, HDL, LDL) were meticulously assessed. Conclusion: The study offers substantial support for the notion that these plants have medicinal potential. The discovery of antidiabetic, anti-hypertensive, anti-inflammatory, and cardioprotective medications in the management of a variety of illness situations may be aided by thorough phytochemical and pharmacological inquiry.