Abstract
Aim: The present study was conducted with the aim to define the incidence and type of field change in clinically apparent normal mucosa of new patients with unilateral oral squamous cell carcinoma (OSCC). Materials and Methods: Biopsy was carried out from clinically apparent normal oral mucosa on the contralateral site (mirror image site) in 38 consecutive newly diagnosed patients with unilateral OSCC. The mirror image tissue was analyzed histologically for abnormal features of dysplasia by two oral pathologists. Results: According to observer 1, 22 (57.89%) mirror image biopsies showed dysplasia of which 19 (50%) mirror image biopsies showed mild dysplasia and 3 (7.89%) mirror image biopsies showed moderate dysplasia. According to observer 2, 17 (44.74%) mirror image biopsies showed dysplasia of which 16 (42.11%) mirror image biopsies showed mild dysplasia and 1 (2.63%) mirror image biopsy showed moderate dysplasia. Conclusions: Histological observation of dysplasia at mirror image site was noted in about half of a sample of cases. Results displayed vulnerability to field change of oral mucosa chronically exposed to carcinogens. It acknowledges the risk for development of second or multiple primary tumors.
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