Abstract
It is morally justifiable for every person of good will to venture into HIV and AIDs prevention among the populace. Pre-exposure Prophylaxis (PrEP) administration promises to help meet the promise of this moral claim, which is founded on two ethical principles of ensuring wellbeing and justice for all. In spite of the efforts, challenges abound, especially in Africa. Some African tenets of sexuality, unavailability of contextualized and harmonized African sexuality theory as well as Africa’s poor economic standing are major threats to the administration of PrEP. This paper highlighted the major challenges and calls for their resolution if PrEP administration is to be of help to the poor and HIV burdened Africans.Key Words: HIV prevention, Preexposure Prophylaxis (PrEP), well-being, justice
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