Abstract
Experiments involving the intranasal inoculation of monkeys, rabbits and guinea pigs with an equine respiratory virus were carried out. The animals were killed at various intervals after inoculation and attempts made to isolate virus in tissue culture from extracts of homogenized tissues and organs. All three species were susceptible, virus reproduction occurring in the respiratory tract and associated lymph glands. Of the three species virus was least readily isolated from the guinea pig tissues. There was a viraemia in monkeys and rabbits, but virus was less readily detected in the blood of guinea pigs. Virus was found in the urine and kidney cultures of some of the animals which had by then developed antibody. A human volunteer intranasally inoculated developed severe pharyngitis and swelling of the pharyngeal lymph glands; viraemia accompanied by fever occurred and lasted 4 days. The virus was unstable at pH 5.0 and below and its stability in distilled water was not increased by the addition of M MgCl2.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
