Abstract
Abstract. Hinkel, G. K., Kintzel, H.‐W., Schwarze, R. and Hiindel, A. (Paediatric Hospital, Medical Academy “Carl Gustav Carus”, Department of Neonatology, Dresden, GDR). Enzyme inductor combination to prevent hyperbilirubinaemia in premature infants. Acta Paediatr Scand, 63: 393, 1974.–In the management of physiologic hyperbilirubinemia in newborn infants, phenobarbital and nicethamide (diethylnicotinamide), as an enzyme inductor combination, are found to have a cumulative effect and, consequently, are clearly superior to the use of phenobarbital alone. Four different dosages were compared and the most favourable variant proved to be phenobarbital, 10 mg/kg body weight pro die from day 1 to day 3 (after birth), combined with nicethamide, 100 mg/kg per diem from day 1 to day 4. Exchange transfusion was no longer necessary in 400 premature infants who had received this type of prophylactic combination and thus the routine use of this inductor regimen can now be recommended.
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