Abstract
AbstractThe present study deals with the biocatalytic enantioselective synthesis of chiral β‐hydroxy ketones. For the first time, we report that among many enzymes, the lipase AL‐AN (Amano Lipase A from Aspergillus niger) catalyzed the enzymatic hydrolysis of racemic 1,3‐keto acetates in aqueous media. Optimum reaction conditions were determined by changing the enzyme, solvent, temperature, pH and amounts of enzymes. After AL‐AN was determined to be the best enzyme in this study, we examined fifteen substrates with different structures in this reaction and obtained chiral β‐hydroxy ketones with good yield, high enantioselectivity and S configuration. This study presents an environmentally friendly and green method for the synthesis of (S)‐β‐hydroxy ketones.
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