Abstract
Summary The viscosity of solutions of calf thymus DNA is decreased after incubation with preparations of chick interferon of low protein content induced either by UV-inactivated NDV virus or by Polyinosonic:polycytidylic acid (poly I:C). The time course of the reaction suggests an endonuclease activity and preliminary analysis of products confirms this. The activity is resistant to pH 2 for 5 days, is not found in mock interferon preparations and is associated with interferon preparations purified by chromatography on CM-Sephadex.
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