Abstract
We report a new synthesis of enantiomerically pure ( S)-4-fluorohisitidine based on diastereoselective alkylation of MOM-protected 4-fluoro-5-bromomethyl imidazole using the Schöllkopf bis-lactim amino acid synthesis. Improvements in procedures for preparation of key intermediates are also described. ( S)-4-Fluorohisitidine prepared by this new method was identical in all respects to material prepared by previous procedures.
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