Abstract
Porous organic cages (POCs) have attracted extensive attention due to their unique structures and tremendous application potential in numerous areas. In this study, an enantioselective potentiometric sensor composed of a polyvinyl chloride (PVC) membrane electrode modified with CC3-R POC material was used for the recognition of enantiomers of 2-amino-1-butanol. After optimisation, the developed sensor exhibited enantioselectivity toward S-2-amino-1-butanol ( = −0.98) with acceptable sensitivity, and a near-Nernstian response of 25.8 ± 0.3 mV/decade within a pH range of 6.0–9.0.
Highlights
Chirality is a general phenomenon and an important characteristic in naturally occurring molecules
Chiral discrimination can be precisely achieved in many ways including gas chromatography (GC), high-performance liquid chromatography (HPLC) and high-performance capillary electrophoresis (HPCE)
The synthesised CC3-R crystals were characterised by Nuclear Magnetic Resonance (NMR), The synthesised synthesised crystalswere werecharacterised characterised by by Resonance (NMR), CC3-R
Summary
Chirality is a general phenomenon and an important characteristic in naturally occurring molecules. Chiral discrimination has attracted tremendous attention on account of its significance in pharmaceutical, biomedicine and chemical fields. Chiral discrimination can be precisely achieved in many ways including gas chromatography (GC), high-performance liquid chromatography (HPLC) and high-performance capillary electrophoresis (HPCE). These methods have different advantages in terms of sensitivity or applicability, they suffer similar drawbacks including complicated operation and the need for expensive equipment. Ion-selective electrodes are simple, rapid and affordable, and have been widely applied to the enantioselective recognition and detection of chiral compounds in recent years [1,2,3,4,5,6,7,8,9]
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