Abstract
ObjectivesIn order to perform the enantioanalysis of L- and D-methionine in whole blood samples, this research suggests a 3D enantioselective stochastic platform. Materials and MethodsThe platform contains a 3D-printed stochastic sensor designed by mixing carbon nanopowder and europium oxide, modified with N-[5-methylpyridin-2-yl] octadec-9-enamide (namely N10-Eu2O3/CNP), an auxiliary Pt electrode, and an Ag/Ag Cl reference electrode. Stochastic method was applied for all measurements. ResultsThe quantification limits of L- and D-methionine were of 10-16 and 10−18 mol/L magnitude order, respectively. High sensitivities and large working concentration ranges were recorded. In whole blood, the enantiomers could be identified with recoveries greater than 99.00 %, and RSD% less than 1.00 %. ConclusionsThe proposed platform can be reliable used for enantioanalysis of methionine in whole blood samples. The preliminary results of the screening tests of whole blood shown that the D-methionine enantiomer is only present in the whole blood of the patients diagnosed with lung carcinoma.
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