An Empirical Investigation of Exposure Measurement Bias and Its Components in Case-Control Studies

Abstract

This study investigated bias due to misclassification of exposure in case control studies. Using a metaanalysis of data from a number of case control studies, in which a possibly misclassified exposure was validated against a more reliable one, estimates of misclassification indices and bias were obtained. The estimates were used to investigate whether misclassification indices, in particular, sensitivity and specificity and so-called quality indices, are typically nondifferential with respect to cases and controls. It is concluded that quality indices do not show any tendency to be either lower or higher in cases than controls. On the other hand, sensitivity tends to be higher in cases than controls and specificity lower. Estimates of misclassification bias may be either positive or negative and are consistent with random variation; there is little to suggest that bias is present in the studies analyzed.