An Emergence of a MRAB: With Growing Necessity of Antibiotic Pharmacist in Infectious Era

Maria A,Somia G

doi:10.4172/2153-2435.1000491

Abstract

Multi-drug Resistant pathogens pose a serious challenge against lifesaving antimicrobials globally. MRAB (multi drug resistant Acinetobacter baumannii) has a capability for extensive adaptation of multi-drug resistance pattern particularly in immune compromised patients which became resistant to carbapenems beta lactamase antimicrobials. The objective of the study is to evaluate multidrug resistance pattern of A. baumannii among broad spectrum antimicrobials with intention to highlight the growing need of antibiotic pharmacist in south Asia to encounter such life threatening multidrug resistance pattern. For the purpose of this study MRAB isolates with sensitivity and resistance pattern carefully evaluated by hospital pharmacist to determine such pattern with rationale utilization of therapy. Resulting data of about 146 isolates of MRAB interpreted by pharmacist which shows about 78% isolates were resistant to more than four broad spectrum antimicrobials. Amoxicillin has been resistant to 90%, Piperacillin 67%, third generation cephalosporin 92% with 75% of fourth generation cefepime, carbapenems 67%, aminoglycosides 75%, quinolones 54% and Polymyxin B 47% resistance respectively. This retrospective studies drawn conclusion that the effective utilization with evaluation of adaptive drug resistance can encounter threats associated with multidrug resistance pathogens and pharmacist can imparts key role in rationale utilization of antimicrobials with growing concern of implementation of specialty role in healthcare sector of south Asia.

Highlights

Multi-drug Resistant pathogens create an emergence against life threatening antimicrobials is a major growing concern and challenging task Globally and in the USA [1,2]
After careful evaluation with hospitals Antibiograms of MRAB All resulting data interpreted by hospital pharmacist with the help of statistical analysis and spss software to provide key pattern of drug resistance adaptive mechanism in MRAB isolates
Resulting Antibiograms of MRAB from different tertiary care center were 75% resistant to 4th generation cephalosporins which clearly reflects less efficacy of beta lactam antibiotics Figure 3 clearly demonstrate 86% resistance against piperacillin, 82% cefepime, Figure 4 and Table 1 shows isolates which were resistant to four drugs involving loss of sensitivity in amikacin & piperacillin 95%, quinolones 92%, cefepime 91% with highest sensitivity shown in carbapenems of 15% respectively

Summary

Introduction

Multi-drug Resistant pathogens create an emergence against life threatening antimicrobials is a major growing concern and challenging task Globally and in the USA [1,2]. Acinetobacter accounts for significant taxonomic variation globally resistant to variety of antimicrobial is a major growing concern for Health sector and create emergence against broad spectrum antimicrobials. This pathogen have prolong survival threshold especially measure leading cause of hospital acquired nosocomial infections. It targets the open skin wounds and respiratory tract infection and mucosal secretions, pneumonia in hospital setting mostly caused by this pathogen it affects bone, nervous system and infection involving soft tissues is major growing concern in hospital settings [8,9,10]

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