An ELIXIR for bone loss?

Abstract

Because the endogenousligands for the novel molecules were unknown, they weredesignated orphan receptors. Third, those orphans whoseendogenous partners were identified became, appropriately,adoptedreceptors.Notably,whilemaintainingthecanonical11–13ahelicalloopstructure,manyoftheorphan/adoptedreceptor(OAR) ligand domains bind multiple agonists.