Abstract
An elegans Solution for Crossover Formation
Highlights
Meiotic crossovers are important for chromosome segregation
COs are produced by cleavage of a late joint molecule (JM) intermediate that has two Holliday junctions (HJs)
This issue of PLOS Genetics contains a set of three papers that describe progress toward answering this question in C. elegans, with regard to functions of resolvases in generating COs [3,4,5] (Figure 1)
Summary
Meiotic crossovers are important for chromosome segregation. When COs are absent or misplaced, nondisjunction results in aneuploidy, a leading cause of miscarriages and birth defects in humans. Key features of the most commonly cited model for meiotic recombination include initiation by a DNA double-strand break (DSB) and a progression of joint molecule (JM) intermediates that link DNA duplexes on homologous chromosomes (reviewed in [1]).
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