Abstract
The design and development of innovative multifunctional wound dressing materials in engineered biomaterials is essential for promoting tissue repair. In this study, nanofibrous wound dressing materials loaded with anti-inflammatory ingredients were manufactured by a promising electrospinning strategy, and their capability for treating diabetic wounds was also investigated. A scaffold blend consisting of an Enteromorpha polysaccharide and polyvinyl alcohol (PVA) was fabricated. The in vitro and in vivo studies confirmed the efficacy of PVA/EPP1 fiber. We found that PVA/EPP1 fiber accelerated the repair of a full-thickness skin wound in diabetic mice. The results suggest that this scaffold could effectively shorten the wound healing time by inhibiting inflammatory activity, which makes it a promising candidate for the treatment of hard-to-heal wounds caused by diabetes.
Highlights
Nowadays, hard-to-heal wounds are one of the most severe diabetic complications, resulting in limb loss and disability
According to the obtained results, we can draw a conclusion that Polyvinyl Alcohol (PVA)/EPP1 fiber has homogenous morphology and a high water absorption capacity for skin repair
After we accomplished the physical characterizations, PVA/EPP1 was selected for further evaluation in vitro and in vivo
Summary
Hard-to-heal wounds are one of the most severe diabetic complications, resulting in limb loss and disability. Recent advances have improved the healing efficacy of conventionally-utilized wound dressing materials by incorporating some bioactive ingredients into the dressing materials, containing growth factors [2] and exosomes [3], which have been demonstrated to accelerate endothelial proliferation and angiogenesis Some demerits, such as the instability of additives and the exorbitant price, severely limit their clinical application. According to the obtained results, we can draw a conclusion that PVA/EPP1 fiber has homogenous morphology and a high water absorption capacity for skin repair. These properties are unquestionably beneficial to the wound healing
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