Abstract
The free-radical content and electron donor properties of tobacco smoke condensates and products formed when these condensates interact with hemoglobin and lung phospholipids have been investigated by electron spin resonance spectroscopy. These studies indicate that tobacco smoke constituents are capable of entering into the blood stream through the lung membranes and then destructively interacting with hemoglobin to: (1) destroy the oxygen-transport capacity by the formation of high spin ferrihemoglobin and low-spin ferrohemoglobin complexes, and (2) remove the iron from the porphyrin ring and form two types of nonheme iron complexes. It has also been established that non free-radical constituents of smoke and smoke condensates interact with hemoglobin and phospholipids to produce stable free-radical species in addition to altering the environment and oxidation state of the heme iron. These radical species have been characterized and evidence is presented which implicates nitrogen oxides as the causative agents.
Published Version
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