Abstract
An electron spin resonance study was performed to investigate the effect of Laurocapram (1-dodecylazacyclo-heptan-2-one, Azone ®) on lipid bilayers of human stratum corneum. 5-Doxylstearic acid (5-DSA) was used as a lipid spin label and incorporated with the untreated and treated stratum corneum. Azone ® led to a significant change in ESR spectra of human stratum corneum — from strongly immobilized to weakly immobilized spectra. The molecular motion of 5-DSA comprising the Azone ®-treated stratum corneum showed an isotropic motion to some extent, which was totally different from the molecular motion of 5-DSA in the untreated stratum corneum. Azone ® reduced order parameters ( S) by 54–80% at different concentrations. The results suggest that Azone ® affected the spin label binding to lipid bilayers and caused an increase in the flexibility and polarity of local bilayers surrounding 5-DSA. The concentration effect of Azone ® and influence of ethanol on the stratum corneum were also investigated.
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