Abstract
To clarify the effect of synthetic motilin on gastric motility, the electromyograms after the bolus injection of synthetic motilin in dogs were investigated. The results were summarized as follows: After the bolus injection of synthetic motilin, the discharge interval was shortened and the propagation velocity was accelerated. Therefore, synthetic motilin stimulated gastric muscle in dogs. The dose-response effect of synthetic motilin on discharge interval was observed. On propagation velocity, the dose-response effect was observed, too. Between motilin and secretin, competitive antagonistic action was observed on electromyographic study. On the occasion of the combined use of motilin and tetragastrin, additive effect was observed. After atropine injection, synthetic motilin stimulated gastric muscle. After vagotomy, synthetic motilin also stimulated gastric muscle. After feeding, it was appeared that synthetic motilin did not stimulated gastric muscle.
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