An Electromicroscopic Study of the Thiamine-Deficient Rat Heart.

Abstract

s1 May 1966An Electromicroscopic Study of the Thiamine-Deficient Rat Heart.F. Eugene Tubbs, M.D., Yoshiharu Sako, M.D., Lamar E. Crevasse, M.D. (Associate)F. Eugene Tubbs, M.D.Search for more papers by this author, Yoshiharu Sako, M.D.Search for more papers by this author, Lamar E. Crevasse, M.D. (Associate)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1154_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThiamine-deficient hearts have been demonstrated by light microscopy to show interstitial edema with hydropic and fatty degeneration of the myocardial fibers. This report is the first ultrastructure study of thiamine-deficient cardiac muscle. Twenty-four adult male Sprague-Dawley rats were divided into two groups. Controls were fed a standard balanced diet containing 2.2 mg of thiamine 100 g of diet. The other group received the same diet, without thiamine. The thiamine-deficient group rapidly developed beri-beri, manifest by weakness, weight loss, epilation and labored respirations. They were given 5 µg of thiamine occasionally to maintain life and induce a chronic deficient state. After... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: F. Eugene Tubbs, M.D.; Yoshiharu Sako, M.D.; Lamar E. Crevasse, M.D. (Associate)Affiliations: Gainesville, Florida PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1966Volume 64, Issue 5Page: 1154-1154KeywordsCardiac musclesDietEdemaHeartLight microscopyLongitudinal studiesRespirationThiamineWeight loss ePublished: 1 December 2008 Issue Published: 1 May 1966 PDF downloadLoading ...