An electrochemical alternative strategy to the synthesis of β-lactams via N [sbnd]C4 bond formation

Abstract

A simple electrochemical synthesis of β-lactams has been developed using constant current electrolysis in a suitable solvent-supporting electrolyte solutions, with subsequent addition of bromoamides. The regio- and stereo-selectivity of the electrochemically-induced cyclization of bromoamides to β-lactams, via N C4 bond formation, has been evidenced. This synthesis avoids any addition of bases and probases and gives β-lactams in high yields.