Abstract
ABSTRACTScandium-47 [T½ = 3.35 d, Eβ-(max.) = 600 keV, Eγ = 159 keV] is a relatively new radioisotope that holds tremendous potential for use in cancer theranostics. The radioisotope was produced by thermal neutron irradiation of enriched 46Ca producing 47Ca, which decays by β− emission to 47Sc. A viable method based on the selective electroamalgamation of Ca2+ ions has been developed for the clinical-scale separation of 47Sc from 47Ca. The overall yield of 47Sc after the separation process was >80% and it was obtained with >99.9% radionuclidic purity in a form suitable for radiopharmaceutical preparation. This strategy holds promise for future clinical translation of this radioisotope.
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