Abstract
Abstract An improved sonochemical condensation has been reported between chloro-substituted hydroxyl chalcones and hydrazine hydrate in 2-ethoxy ethanol as an efficient & alternative reaction medium in presence of sodium acetate and acetic acid to afford 2-pyrazolines. The pyrazolines were obtained in good to excellent yields (80–90%), and were characterized by conventional spectral data and evaluated for their antimicrobial potential. It is observed that the work-up is simple and the results obtained indicate that, unlike classical heating, ultrasound irradiation results in higher yields, shorter reaction times (1.5–2.5 h) and milder reaction conditions. The investigation of antimicrobial potential revealed that all the synthesized compounds shows good to moderate growth inhibiting effect against microorganism tested.
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