An Efficient Synthesis of α‐Sulfonamide Phosphonates through Metal‐Free Three‐Component Reaction

Abstract

A metal‐free three‐component reaction for the direct synthesis of α‐sulfonamide phosphonates involving sulfonamide derivatives, benzaldehyde derivatives, and diethyl phosphite, has been achieved with high yields using ethanol as a green solvent. This efficient method reduces reaction time and minimizes the use of excess reagents. Hitherto, no reports have been found in the literature for the direct synthesis of α‐sulfonamide phosphonates from the readily available aldehydes, diethyl phosphite, and sulfonamides, emphasizing the novelty and significance of this work.