Abstract
1-anilinocyclohexanecarboxamides 2a-c were found to be a versatile precursors for the synthesis of five-, six- and seven-membered ring spiroheterocycles compounds 3-14. A general high yielding protocol for the synthesis of many functionalized spiro heterocyclic systems was presented.
Highlights
Spiro-compounds form a group of generally less investigated compounds
Spiro compounds have been recently used as antioxidants [19,20]
Nitrogen containing heterocyclic compounds constitute the largest portion of chemical entities, which are part of many natural products, fine chemicals, and biologically active pharmaceuticals vital for enhancing the quality of life [21]
Summary
Spiro-compounds form a group of generally less investigated compounds. recently growing efforts have been made to synthesize and characterize these compounds. Many spiro compounds possess very promising biological activities as anticancer agents [1,2], antibacterial agents [3,4], anticonvulsant agents [5,6,7], antituberculosis agents [8], anti-Alzheimer’s agents [9], pain-relief agents [10,11], anti-dermatitis agents [12] and antimicrobial agents [13,14]. In addition to their medical uses, some spiro-compounds have found other uses in the agricultural and industrial fields. Among a large variety of nitrogen containing heterocyclic compounds, heterocycles containing a spiro system are of interest because they constitute an important class of natural and nonnatural products, many of which exhibit useful biological activities and clinical applications [21]
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