Abstract
Seven-, eight-, and nine-membered cyclic β-amino acids, precursors of platelet aggregation inhibitors, were synthesized for the first time starting from N-alkenyl amines and ethyl acrylate via ring-closing metathesis (RCM) as the key reaction. Synthesis of the corresponding enantiomerically pure β-amino acids was also accomplished in a similar manner using Evans' asymmetric allylation.
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