Abstract
A facile, rapid and cheap synthetic strategy towards a wide range of novel 2-aminoethylidene-1,1-bisphosphonate derivatives was developed through the Michael addition reaction of various aromatic amines, aromatic amides as well as nucleoside analogues with tetraethyl ethenylidene-1,1-bisphosphonate. All the newly obtained compounds were characterized by 1 H, 31 P, 13 C NMR spectroscopy, IR and HR MS.
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