An efficient synthesis of 2-amino-3-cyano-2-pyrrolin-4-ones, via the corresponding open chain tautomers (aminoacetylmalononitriles)

Abstract

Malononitrile has been found to be acylated effectively using N-protected glycines by simultaneous activation of an amino acid carbonyl group and a malononitrile methylene group using carbonyl diimidazole (CDI). The corresponding aminoacetonitriles were isolated as enols and/or as their tautomeric forms, 2-amino-3-cyano-2-pyrrolin-4-ones.